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Scientific experiments have not been executed with Promethazine with Codeine Oral Remedy in geriatric populations. Use warning when considering the usage of Promethazine with Codeine Oral Option in sufferers 65 many years of age or more mature. Elderly people can have elevated sensitivity to codeine; higher frequency of reduced hepatic, renal, or cardiac functionality; or concomitant condition or other drug therapy [see Warnings and Safety measures (five.six)]. Respiratory depression is definitely the chief danger for aged patients treated with opioids, which include Promethazine with Codeine Oral Answer.

Little ones Postmarketing instances of respiratory depression, together with fatalities, are already reported with use of promethazine in pediatric sufferers. Concomitant administration with other respiratory depressants may improve the possibility of respiratory depression.

Carcinogenicity, mutagenicity, and fertility studies have not been performed with Promethazine with Codeine Oral Remedy; nonetheless, revealed facts is obtainable for the person Energetic elements.

Lactation At least one particular Demise was documented in the nursing infant who was subjected to substantial levels of morphine in breast milk because the mother was an ultra-rapid metabolizer of codeine.

Promethazine is contraindicated in comatose states, and in folks identified to generally be hypersensitive or to obtain experienced an idiosyncratic reaction to promethazine or to other phenothiazines.

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You may have an elevated danger of the allergic response to Promethazine with Codeine Oral Solutionif you're allergic to specified other opioid medicines

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Marketing or gifting away wockhardt w/ codeine cough syrup might damage others, and is also from the legislation. Explain to your Health care provider Should you have at any time abused or been depending on Alcoholic beverages, prescription medicines or street prescription drugs

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Codeine Printed read more details from situation-control and observational research on codeine use during pregnancy are inconsistent of their findings. Some experiments of codeine exposure confirmed an elevated threat of All round congenital malformations click here while some did not.

Prevent the use of Promethazine and Codeine Oral Option when you: are pregnant. Utilization of Promethazine check here and Codeine Oral Alternative during pregnancy can result in withdrawal symptoms with your new child newborn that may be lifetime-threatening Otherwise recognized and taken care of. Convey to your healthcare supplier straight away When you are Expecting or Believe you could be Expecting.

Promethazine is metabolized with the liver to a number of compounds; the sulfoxides of promethazine and N-demethylpromethazine tend to be the predominant metabolites showing in the urine.